Journal
ACS CATALYSIS
Volume 9, Issue 5, Pages 4271-4276Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b04415
Keywords
palladium; alkylation; alkenyl C-H activation; bidentate directing group; stereospecific
Categories
Funding
- National Natural Science Foundation of China [21672198, 21871240]
- State Key Program of National Natural Science Foundation of China [21432009]
- Fundamental Research Funds for the Central Universities [WK2060190082]
Ask authors/readers for more resources
A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate to good yields. Mechanistic studies suggest that alkenyl C-H bond activation is the rate-determining step.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
