Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-09235-5
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Funding
- Marie Curie Intra-European Fellowship [328935]
- Alfred and Anneliese Sutter-Stottner Foundation
- Center for Adaptation to a Changing Environment (ACE) at ETH Zurich
- Max Planck Society
- University of Munster
- University of Muenster
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Mutation rate and effective population size (N-e) jointly determine intraspecific genetic diversity, but the role of mutation rate is often ignored. Here we investigate genetic diversity, spontaneous mutation rate and N-e in the giant duckweed (Spirodela polyrhiza). Despite its large census population size, whole-genome sequencing of 68 globally sampled individuals reveals extremely low intraspecific genetic diversity. Assessed under natural conditions, the genome-wide spontaneous mutation rate is at least seven times lower than estimates made for other multicellular eukaryotes, whereas N-e is large. These results demonstrate that low genetic diversity can be associated with large-N-e species, where selection can reduce mutation rates to very low levels. This study also highlights that accurate estimates of mutation rate can help to explain seemingly unexpected patterns of genome-wide variation.
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