Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-09145-6
Keywords
-
Categories
Funding
- National Natural Science Fund for Distinguished Young Scholar [31525020]
- National Key R&D Program of China [2017YFC1600900]
- National Science Foundation [31571945, 31871910, 31801675]
- China Agriculture Research System [CARS-3-1-15]
- Fundamental Research Funds for the Central Universities [2017FZA6014]
- China Postdoctoral Science Foundation [2017M620250]
- International Postdoctoral Exchange Fellowship Program
- Dabeinong Funds for Discipline Development and Talent Training in Zhejiang University
- USDA National Institute of Food and Agriculture [2014-67013-21561]
Ask authors/readers for more resources
Sterol biosynthesis is controlled by transcription factor SREBP in many eukaryotes. Here, we show that SREBP orthologs are not involved in the regulation of sterol biosynthesis in Fusarium graminearum, a fungal pathogen of cereal crops worldwide. Instead, sterol production is controlled in this organism by a different transcription factor, FgSR, that forms a homodimer and binds to a 16-bp cis-element of its target gene promoters containing two conserved CGAA repeat sequences. FgSR is phosphorylated by the MAP kinase FgHog1, and the phosphorylated FgSR interacts with the chromatin remodeling complex SWI/SNF at the target genes, leading to enhanced transcription. Interestingly, FgSR orthologs exist only in Sordariomycetes and Leotiomycetes fungi. Additionally, FgSR controls virulence mainly via modulating deoxynivalenol biosynthesis and responses to phytoalexin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
