Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 45, Pages 14085-14089Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605548
Keywords
boronic esters; cross-coupling; flow chemistry; photoredox catalysis; synthetic methods
Categories
Funding
- Novartis Pharma AG
- EPSRC [EP/K0099494/1, EP/K039520/1]
- EPSRC [EP/K009494/1, EP/K039520/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K009494/1, EP/K039520/1] Funding Source: researchfish
Ask authors/readers for more resources
We report herein a new method for the photoredox activation of boronic esters. Using these reagents, an efficient and high-throughput continuous flow process was developed to perform a dual iridium- and nickel-catalyzed C(sp(2))-C(sp(3)) coupling by circumventing solubility issues associated with potassium trifluoroborate salts. Formation of an adduct with a pyridine-derived Lewis base was found to be essential for the photoredox activation of the boronic esters. Based on these results we were able to develop a further simplified visible light mediated C(sp(2))-C(sp(3)) coupling method using boronic esters and cyano heteroarenes under flow conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available