Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-08259-7
Keywords
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Funding
- Common Fund of the Office of the Director of the National Institutes of Health
- NCI
- NHGRI
- NHLBI
- NIDA
- NIMH
- NINDS
- Wellcome Trust Institutional Strategic Support Award [WT097835MF]
- European Research Council [SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC, 323195]
- Royal Society [104150/Z/14/Z]
- Wellcome Trust [104150/Z/14/Z]
- Diabetes Research and Wellness Foundation Fellowship
- UK Medical Research Council [MC_UU_00011/6]
- European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC [669545]
- Wellcome Investigator award [107849/Z/15/Z.]
- NIH [R01DK102696, F32DK102323, 4T32HL007901, R01DK107859]
- University of Manchester Research Infrastructure Fund
- National Health and Medical Research Council of Australia [1145645, 1078901, 1087889]
- MGH Research Scholar Fund
- Dutch Medical Research Foundation [016.VICI.170.200, VIDI 017.106.370]
- Medical Research Council [MR/M005070/1]
- University of Bristol [MC_UU_00011/3]
- Wellcome Trust [104150/Z/14/Z] Funding Source: researchfish
- MRC [MC_UU_12013/5, MR/M005070/1, MR/P012167/1, MR/P023576/2, MC_UU_00011/2] Funding Source: UKRI
- Wellcome Trust [104150/Z/14/Z, 107849/Z/15/Z] Funding Source: Wellcome Trust
- National Health and Medical Research Council of Australia [1145645] Funding Source: NHMRC
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Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
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