Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 31, Pages 9017-9020Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602480
Keywords
catalysis; copper; peptides; self-assembly; supramolecular chemistry
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Funding
- NSF-EFRI [1332349]
- ORAU Ralph E. Powe Junior Faculty Enhancement award
- Humboldt Fellowship
- NIH [P41GM103521]
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [1332349] Funding Source: National Science Foundation
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We have shown that de novo designed peptides self-assemble in the presence of copper to create supramolecular assemblies capable of carrying out the oxidation of dimethoxyphenol in the presence of dioxygen. Formation of the supramolecular assembly, which is akin to a protein fold, is critical for productive catalysis since peptides possessing the same functional groups but lacking the ability to self-assemble do not catalyze substrate oxidation. The ease with which we have discovered robust and productive oxygen activation catalysts suggests that these prion-like assemblies might have served as intermediates in the evolution of enzymatic function and opens the path for the development of new catalyst nanomaterials.
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