Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-08261-z
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Funding
- Canadian Institutes of Health Research (CIHR Project Grant)
- Medicine-by-Design Cycle 1 Team Projects Award [C1TPA-2016-07]
- Toronto General & Western Hospital Foundation [1013612]
- XVIVO Perfusion
- Brazilian agency Sao Paulo Research Foundation) [FAPESP CEPOF 2013/07276-1, INCT 2014/50857-8]
- Brazilian agency National Council for Scientific and Technological Development [CNPq 465360/2014-9]
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Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development.
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