Journal
EPIGENOMICS
Volume 11, Issue 4, Pages 411-421Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2018-0111
Keywords
breast cancer; breast carcinoma; carcinogenesis; circular RNA; exosomes; extracellular vesicles; invasiveness; metastasis; miRNA; pathway
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Funding
- National Natural Science Foundation of China [81602551]
- young talents program of Jiangsu Cancer Hospital [2017YQL-10]
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Aim: We aimed to explore the roles of circular RNAs (circRNAs) in breast cancer (BCa). Materials & methods: RNA was extracted from exosomes and BCa cells and analyzed using the RNA sequencing technique or microarray. Results: Compared with controls, 1147 and 1195 circRNAs were dysregulated in exosomes from metastatic and localized BCa patients, respectively. A total of 480 dysregulated circRNAs were found in metastatic patients compared with localized patients, and these dysregulated circRNAs were enriched in eight pathways. Compared with MCF-7 cells and their exosomes, there were 5842 and 1137 dysregulated circRNAs in MDA-MB-231 cells and exosomes, respectively, and 5 circRNAs were confirmed using real-time quantitative PCR. Conclusion: We identified a number of dysregulated circRNAs in exosomes from BCa cells and patients.
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