Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 4, Pages 601-605Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00589
Keywords
Fragment-based approach; anticancer agent; one-pot microwave reaction; JMJD3 inhibitor; melanoma
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Fondazione Cariplo [17099]
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JMJD3 is a member of the KDM6 subfamily and catalyzes the demethylation of lysine 27 on histone H3 (H3K27). This protein was identified as a useful tool in understanding the role of epigenetics in inflammatory conditions and in cancer as well. Guided by a virtual fragment screening approach, we identified the benzoxazole scaffold as a new hit suitable for the development of tighter JMJD3 inhibitors. Compounds were synthesized by a microwave-assisted one-pot reaction under catalyst and solvent-free conditions. Among these, compound 8 presented the highest inhibitory activity (IC50 = 1.22 0.22 /./M) in accordance with molecular modeling calculations. Moreover, 8 induced the cycle arrest in S-phase on A375 melanoma cells.
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