Journal
CELL DEATH & DISEASE
Volume 10, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41419-019-1315-9
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Funding
- National Natural Science Foundation of China [81472874, 81401346]
- Foundation of Shanghai Municipal Commission of Health and Family Planning [201640096]
- Cultivation Plan of Young Doctor of Shanghai
- Outstanding Talent Plan of Zhongshan Hospital, Fudan University [2015ZSYXGG13]
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Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine protein, inhibit anti-ds-DNA antibody titers, and ameliorate lupus nephritis in MRL/lpr lupus-prone mice. Baicalin inhibited Tfh cell differentiation and IL-21 production, but promoted Foxp3(+) regulatory T cell differentiation including part of follicular regulatory T (Tfr) cells. Intravenous injection of Baicalin-induced Foxp3(+) regulatory T cells could relieve nephritis, inhibit Tfh cell differentiation and IL-21 production. Baicalin inhibited mTOR activation, reduced mTOR agonist-mediated Tfh cell expansion and increased Tfr cells. These data suggest that Baicalin attenuates lupus autoimmunity by up-and downregulating the differentiation of Tfr cells and Tfh cells, respectively. Baicalin and ex vivo expanded Foxp(3+) regulatory T cells are promising therapeutics for the treatment of lupus.
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