Related references
Note: Only part of the references are listed.Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Wei Yan et al.
NATURE CELL BIOLOGY (2018)
A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability
Jingjiang Pi et al.
CIRCULATION RESEARCH (2017)
Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation
Lorenz Adlung et al.
MOLECULAR SYSTEMS BIOLOGY (2017)
Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7
Jia Yu et al.
CELL REPORTS (2017)
USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling
Kuntian Luo et al.
EMBO JOURNAL (2017)
miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma
Nahikari Bartolome-Izquierdo et al.
BLOOD (2017)
HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3
K. Yuan et al.
CELL DEATH AND DIFFERENTIATION (2016)
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
Sonja M. Woermann et al.
GASTROENTEROLOGY (2016)
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Evan C. Lien et al.
NATURE CELL BIOLOGY (2016)
Periostin promotes the chemotherapy resistance to gemcitabine in pancreatic cancer
Yang Liu et al.
TUMOR BIOLOGY (2016)
Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
Nisebita Sahu et al.
NATURE COMMUNICATIONS (2016)
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
Sherry Y. Wu et al.
NATURE COMMUNICATIONS (2016)
Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
Chi Lam Au Yeung et al.
NATURE COMMUNICATIONS (2016)
Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways
A. Nabeshima et al.
BRITISH JOURNAL OF CANCER (2015)
Cancer Statistics, 2015
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2015)
Gemcitabine resistance in pancreatic ductal adenocarcinoma
Yoav Binenbaum et al.
DRUG RESISTANCE UPDATES (2015)
Circulating plasma microRNAs as a screening method for detection of colorectal adenomas
Ajay M. Verma et al.
LANCET (2015)
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer et al.
NATURE (2015)
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Lin Zhang et al.
NATURE (2015)
Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong et al.
NATURE CELL BIOLOGY (2015)
CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27Kip1 via Skp2 and FOXO3a regulation
I. Haque et al.
ONCOGENE (2015)
CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma
Megan E. Murray et al.
BLOOD (2014)
MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer
Nicola Valeri et al.
CANCER CELL (2014)
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth
Yuan Yin et al.
CELL RESEARCH (2014)
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
Xingnan Zheng et al.
GENES & DEVELOPMENT (2014)
ZIC1 Is a Putative Tumor Suppressor in Thyroid Cancer by Modulating Major Signaling Pathways and Transcription Factor FOXO3a
Wei Qiang et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
The Tyrphostin NT157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer
Naokazu Ibuki et al.
MOLECULAR CANCER THERAPEUTICS (2014)
被撤回的出版物: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 (Retracted article. See vol. 582, pg. 134, 2020)
Jing Y. Krzeszinski et al.
NATURE (2014)
Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen
Thomas Hartmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance
Oscar Tapia et al.
VIRCHOWS ARCHIV (2014)
Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study
Hideki Ueno et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
Joshua E. Allen et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death
Holly A. Porter et al.
EXPERIMENTAL CELL RESEARCH (2012)
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation
E. Rao et al.
LEUKEMIA (2012)
The Insulin Receptor Substrate 1 (Irs1) in Intestinal Epithelial Differentiation and in Colorectal Cancer
Diana L. Esposito et al.
PLOS ONE (2012)
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
Guri Tzivion et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
Nam Hee Kim et al.
JOURNAL OF CELL BIOLOGY (2011)
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide
Praveen K. Sharma et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth
A. McGarry Houghton et al.
NATURE MEDICINE (2010)
FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt
Huadong Pei et al.
CANCER CELL (2009)
A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer
Jer-Yen Yang et al.
CLINICAL CANCER RESEARCH (2009)
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
Ramin Massoumi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Ben Langmead et al.
GENOME BIOLOGY (2009)
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
Veronique Nogueira et al.
CANCER CELL (2008)
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
NATURE CELL BIOLOGY (2008)
Regulation of VeGF-mediated angiogenesis by the Akt/PKB substrate Girdin
Tomoya Kitamura et al.
NATURE CELL BIOLOGY (2008)
Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
Shannon L. Gibson et al.
CELL CYCLE (2007)
Evi1 is a survival factor which conveys resistance to both TGFb-β and taxol-mediated cell death via PI3K/AKT
Y. Liu et al.
ONCOGENE (2006)
Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
S Brand et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
HG Wendel et al.
NATURE (2004)
The Akt pathway: Molecular targets for anti-cancer drug development
CS Mitsiades et al.
CURRENT CANCER DRUG TARGETS (2004)
Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
A Arlt et al.
ONCOGENE (2003)
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
LY Rui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel et al.
NATURE (2001)
Share Paper
