Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 53, Issue -, Pages 7-21Publisher
ELSEVIER
DOI: 10.1016/j.jff.2018.12.007
Keywords
NAFLD; Fisetin; TACE/TNF-alpha; Liver inflammation and lipid accumulation; NASH
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81703527]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0356]
- School-level research Program of Chongqing University of Education [KY201710B, 17GZKP01]
- Advanced programs of Post-doctor of Chongqing [2017LY39]
- Fundamental Research Funds for the Central Universities [021314380120]
Ask authors/readers for more resources
Excess fat-rich diet ingestion predisposes the liver to non-alcoholic fatty liver disease (NAFLD), but the mechanism is complicated. Fisetin (Fn) as a natural flavonoid with many bio-activities was determined in a number of diseases models. TACE (tumor necrosis factor-alpha-converting enzyme)-combined tumor necrosis factor-alpha (TACE/TNF-alpha) signaling played a significant role in inflammation-associated diseases. The study aimed to explore the protective mechanisms of Fn against high fat diet (HFD)-induced nonalcoholic steatohepatitis (NASH), with particular focus on TACE/TNF-alpha signaling. HFD-fed C57BL/6 mice were used as the metabolic syndrome model to explore the effects of Fn on NASH and to determine whether TACE/TNF-alpha activation was involved in the process. Indeed, HFD increases systemic metabolic disorder, promotes circulating levels of pro-inflammatory cytokines produce, aggravates development of hepatic inflammation, resulting in inflammation overload-associated excessive activation of TACE/TNF-alpha, ultimately induces hepatic lipid accumulation and NASH. Fisetin protected against HFD-induced liver inflammation and lipid accumulation by decreasing metabolic disorder and inflammation overload-related TACE/TNF-alpha activation, inhibiting over-expression of pro-inflammatory cytokines, negatively regulating HFD-triggered abnormal lipid metabolism-related genes expression, finally restricting lipid deposition and hepatic steatosis. Fisetin suppressed HFD-induced liver inflammation and lipid accumulation by decreasing metabolic disorder and hepatic inflammation overload-related TACE/TNF-alpha activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available