Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 51, Pages 15816-15820Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608001
Keywords
borates; mars; prebiotic chemistry; ribonucleosides; rna world
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Funding
- NASA exobiology and astrobiology programs [NNX14AK37G]
- Templeton World Charity Foundation
- John Templeton Foundation-FfAME initiative for the origins of life
- JSPS KAKENHI [15K13588]
- University of Craiova
- Grants-in-Aid for Scientific Research [15H02144, 15K13588] Funding Source: KAKEN
- NASA [680422, NNX14AK37G] Funding Source: Federal RePORTER
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RNA is currently thought to have been the first biopolymer to support Darwinian natural selection on Earth. However, the phosphate esters in RNA and its precursors, and the many sites at which phosphorylation might occur in ribonucleosides under conditions that make it possible, challenge prebiotic chemists. Moreover, free inorganic phosphate may have been scarce on early Earth owing to its sequestration by calcium in the unreactive mineral hydroxyapatite. Herein, it is shown that these problems can be mitigated by a particular geological environment that contains borate, magnesium, sulfate, calcium, and phosphate in evaporite deposits. Actual geological environments, reproduced here, show that Mg2+ and borate sequester phosphate from calcium to form the mineral luneburgite. Ribonucleosides stabilized by borate mobilize borate and phosphate from luneburgite, and are then regiospecifically phosphorylated by the mineral. Thus, in addition to guiding carbohydrate pre-metabolism, borate minerals in evaporite geoorganic contexts offer a solution to the phosphate problem in the RNA first model for the origins of life.
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