Journal
VETERINARY MICROBIOLOGY
Volume 230, Issue -, Pages 178-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2019.01.020
Keywords
Infectious bronchitis virus; Genotype; Serotype; Recombination event; Affinity
Categories
Funding
- National Key Research and Development Program of China [2017YFD0500105]
- China Agriculture Research System [CARS-40-K18]
- National Twelfth Five-Year Plan for Science & Technology Support [2015BAD12B03]
- Provincial Supported Science Foundation of Heilongjiang Province for The National Key Technology RD Program [GX168003]
Ask authors/readers for more resources
Recombination events are known to contribute to the emergence of novel infectious bronchitis virus (IBV) genotypes. In this study, we carried out detailed phylogenetic analysis and sequence comparisons based on 74 complete nucleotide sequences of the IBV S1 gene, including strain 10636/ 16 and 73 representative sequences from each genotype and lineage. The results showed that strain 10636/16 represented a novel genotype, designated as lineage 1 within genotype VII (GVII-1). Further comparative genomic analysis revealed at least two recombination sites that replaced the spike gene in a lineage 18 within genotype I (GI-18)-like virus with an as-yet-unidentified sequence, likely derived from another IBV strain, resulting a novel serotype with a lower affinity to the respiratory tract in chickens. To the best of our knowledge, this provides the first evidence for recombination leading to replacement of the complete spike gene and the emergence of a novel genotype/serotype with a lower affinity to the respiratory tract in chickens comparing to one of its parental virus ck/CH/LGX/ 111119. These results emphasize the importance of limiting exposure to novel IBVs that may serve as a source of genetic material for emerging viruses, as well as the importance of IBV surveillance in chicken flocks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available