Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 12, Pages 3972-3976Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201511521
Keywords
carbon dioxide fixation; heterocycles; homogeneous catalysis; Lewis acids; small ring systems
Categories
Funding
- Spanish Ministerio de Economia y Competitividad (MINECO) [CTQ-2014-60419-R]
- Severo Ochoa Excellence Accreditation [SEV-2013-0319]
- European Community through a Marie Curie Intra-European Fellowship [622587]
- ICREA Funding Source: Custom
Ask authors/readers for more resources
Substituted epoxy alcohols and amines allow substrate-controlled conversion of CO2 into a wide range of heterocyclic structures through different mechanistic manifolds. This new approach results in an unusual scope of CO2-derived products by initial activation of CO2 through either the amine or alcohol unit, thus providing nucleophiles for intramolecular epoxy ring opening under mild reaction conditions. Control experiments support the crucial role of the amine/alcohol fragment in this process with the nucleophile-assisted ring-opening step following an S(N)i pathway, and a 5-exo-tet cyclization, thus leading to heterocyclic scaffolds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available