Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 45, Issue 2, Pages 282-300Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.09.020
Keywords
Ultrasound contrast agent; Microbubble; Non-linear; Resonance; Subharmonic; Oscillation; Scattering; Dynamics; Shell properties; Rayleigh-Plesset
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Ultrasound contrast agent microbubbles have expanded the utility of biomedical ultrasound from anatomic imaging to the assessment of microvascular blood flow characteristics and ultrasound-assisted therapeutic applications. Central to their effectiveness in these applications is their resonant and non-linear oscillation behaviour. This article reviews the salient physics of an oscillating microbubble in an ultrasound field, with particular emphasis on phospholipid-coated agents. Both the theoretical underpinnings of bubble vibration and the experimental evidence of non-linear encapsulated bubble dynamics and scattering are discussed and placed within the context of current and emerging applications. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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