Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 11, Pages 3729-3733Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510947
Keywords
antioxidants; ascorbic acid; ebselen; selenium; cytotoxicity
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Funding
- DRDO
- DST New Delhi [EMR/2015/000061]
- IISER Bhopal
- Swedish Research Council
- Carl Tryggers Stiftelse [CTS 13:346, CTS 13:120]
- Ollie and Elof Ericssons Stifelse for Vetenskaplig Forskning
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Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than -tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25m, the ebselenol derivatives showed minimal toxicity in pre-osteoblast MC3T3cells.
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