Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 7, Pages 575-588Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.01.003
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Funding
- Lundbeck Foundation
- Danish Cancer Society
- Novo Nordisk Foundation
- Danish Council for Independent Research (Natural Sciences)
- National Institute of General Medical Sciences [1R01GM109110]
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The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In medicine, genome sequencing has revealed millions of missense variants that change protein sequences, yet we only understand the molecular and phenotypic consequences of a small fraction. Within protein science, high-throughput deep mutational scanning experiments enable us to probe thousands of variants in a single, multiplexed experiment. We review efforts that bring together these topics via experimental and computational approaches to determine the consequences of missense variants in proteins. We focus on the role of changes in protein stability as a driver for disease, and how experiments, biophysical models, and computation are providing a framework for understanding and predicting how changes in protein sequence affect cellular protein stability.
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