Journal
TRANSPLANTATION
Volume 103, Issue 7, Pages 1323-1337Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0000000000002690
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Funding
- National Institutes of Health (NIH) [5T32HL00785419]
- American Association for the Study of Liver Diseases Career Development Award in the Memory of the University of Michigan Transplant Team
- NIHNIAID [R56 AI122332]
- National Center for Advancing Translational Sciences, NIH [UL1TR001873]
- United Therapeutics
- Jr. Foundation Award
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001873] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007854] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI122332] Funding Source: NIH RePORTER
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The human liver is an organ with a diverse array of immunologic functions. Its unique anatomic position that leads to it receiving all the mesenteric venous blood, combined with its unique micro anatomy, allows it to serve as a sentinel for the body's immune system. Hepatocytes, biliary epithelial cells, Kupffer cells, stellate cells, and liver sinusoidal endothelial cells express key molecules that recruit and activate innate and adaptive immunity. Additionally, a diverse array of lymphoid and myeloid immune cells resides within and traffics to the liver in specific circumstances. Derangement of these trafficking mechanisms underlies the pathophysiology of autoimmune liver diseases, nonalcoholic steatohepatitis, and liver transplantation. Here, we review these pathways and interactions along with potential targets that have been identified to be exploited for therapeutic purposes.
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