Journal
TOPICS IN COMPANION ANIMAL MEDICINE
Volume 35, Issue -, Pages 11-17Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.tcam.2019.03.002
Keywords
dog; hypodontia; oligodontia; conoid teeth; alopecia; hypotrichosis; EDA pathway
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X-linked hypohidrotic ectodermal dysplasia (XLHED) is a genetic disorder characterized by abnormalities in ectodermal derivatives such as sweat glands, hair, and teeth. In animals, the highest number of cases has been reported in dogs, which show characteristic congenital alopecia and develop abnormalities in the shape and number of teeth. Although the clinical phenotype of the affected individuals is typical, this disorder remains almost unknown in veterinary clinical practice. With the aim of making it better known, we gathered in this review the main clinical and genetic aspects of XLHED, placing emphasis on dental abnormalities. (C) 2019 Elsevier Inc. All rights reserved.
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