Journal
TALANTA
Volume 194, Issue -, Pages 941-959Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2018.10.088
Keywords
Multiple response optimization; Graphical optimization; Desirability function; Multiple-response function; Chromatographic response functions
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnoltigico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [457886/2014-5]
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This manuscript covers the application of the main techniques for simultaneous optimization of multiple responses generated by the application of multivariate designs (two-factor factorial, Central Composite, Doehlert, etc.) or by chromatographic runs in the development of analytical methods. Special attention will be given to the graphical method, desirability function, multiple response function and chromatographic response functions, since they are more frequently used in the analytical area. The advantages, disadvantages, limitations, and potentialities of these methods will also be addressed, as well as some of their applications, commenting on real examples from the literature. Some less usual methods in multiple response optimization in Analytical Chemistry will also be commented.
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