Journal
SYNTHESIS-STUTTGART
Volume 51, Issue 8, Pages 1746-1752Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1612303
Keywords
isothiocyanate; green alternatives to thiophosgene; sulfur; tandem Staudinger; aza-Wittig reactions
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Funding
- NIH/DHHS [1R01Al121364-01A1]
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Isothiocyanates (ICTs) are a group of molecules that can be used for many different purposes, they exhibit anticancer, antimicrobial, antibiotic, and anti-inflammatory properties. The synthesis of isothiocyanates has been a focus of many researchers for nearly the past 100 years. One of the most common synthetic methods is to form a dithiocarbamate salt, either as the first step or in situ, and then treat the salt with a desulfurization agent to reach the isothiocyanate. There are many different desulfurization agents available. Among these, there are eleven in particular that will be discussed in this short review, namely thiophosgene, lead nitrate, ethyl chloroformate, hydrogen peroxide, triphosgene, iodine, cobalt, copper, sodium persulfate, claycop, and tosyl chloride. There are four additional particular methodologies that stand out from the literature available on this topic that will be covered, namely the production of isothiocyanates from hydroximoyl chlorides, via elemental sulfur, microwave-assisted synthesis, and through the tandem Staudinger/aza-Wittig reactions.
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