Journal
SMALL
Volume 15, Issue 26, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201805552
Keywords
CpG motif; DNA nanostructures; DNA nanotechnology; self-assembly
Categories
Funding
- ONR [N00014-15-1-2707]
- Fundamental Research Funds for the Central Universities, China [XDJK2016A015]
- Chongqing Research Program of Basic Research and Frontier Technology, China [cstc2018jcyjAX0482]
- Science and Technology Department of Sichuan Province, China [2015FZ0070]
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DNA is a superb molecule for self-assembly of nanostructures. Often many DNA strands are required for the assembly of one DNA nanostructure. For lowering the cost of synthesizing DNA strands and facilitating the assembly process, it is highly desirable to use a minimal number of unique strands for potential technological applications. Herein, a strategy is reported to assemble a series of DNA microparticles (DNA mu Ps) from one component DNA strand. As a demonstration of the application of the resulting DNA mu Ps, the design and assembled DNA mu Ps are modified to carry additional single-stranded tails on their surfaces. The modified DNA mu Ps can either capture other nucleic acids or display CpG motifs to stimulate immune responses.
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