Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 290, Issue -, Pages 249-257Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.03.129
Keywords
PdCu nanoparticles; Carbon black; Sensor; Hydrogen peroxide; Cells
Funding
- Natural Science Foundation of China [21605077, 21705050]
- Pearl River S&T Nova Program of Guangzhou [201806010170]
- Opening Project of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University [2016014, 2016020]
- PhD Start-up Fund of Natural Science Foundation of Guangdong Province, China [2017A030310347]
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Hydrogen peroxide (H2O2) is a major metabolite of oxygen known as reactive oxygen species (ROS) in living organisms. Monitoring H2O2 released from living cells is of great significance as its concentration level is related to several diseases, which imposes stricter requirements on the sensitivity of detection technology. In this work, we have found that carbon black (CB) could preserve bimetallic PdCu alloy's nanostructure, meanwhile improve the dispersion of nanoparticles, provided high conductivity and large specific surface area, thus the PdCu/CB nanohybrid exhibited enhanced electroanalytical performance of H2O2. Under the optimal conditions, the PdCu/CB nanohybrid modified electrode showed a low detection limit of 54 nM with a wide detection range from 0.4 mu M to 5.0 mM. Finally, the application of PdCu/CB/GCE in real-time monitoring H2O2 released from Raw 264.7 cells was achieved, suggesting the PdCu/CB nanohybrid was the promising nanomaterial in monitoring physiological processes.
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