Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 281, Issue -, Pages 871-877Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.10.155
Keywords
Hydrogen polysulfide; Fluorescent probe; Living cells; Lung tissues
Funding
- National Nature Science Foundation of China [81671858, 81801869]
- Major Projects of the PLA Medical Science and Technology [AWS11C004, 08]
- Shanghai Municipal Commission of Health and Family Planning Science and Research Fund [20164Y0205]
- Shanghai Municipal Commission of Health and Family Planning (New prevention and treatment methods for sulfur mustard poisoning)
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Hydrogen polysulfide (H2Sn) has attracted increasing attention since H2Sn instead of H2S has been shown to be the actual signaling molecule in physiological and pathological processes. Thus, developing accurate and sensitive assays for H2Sn detection is urgently needed in biological science. In this work, we developed a red emitting mitochondria-targeting fluorescent probe, HQO-PSP, that is capable of tracking H2Sn. With low cytotoxicity, good selectively and high sensitively, HQO-PSP was able to detect H2Sn in living cells. Furthermore, we also demonstrated that HQO-PSP could also be successfully applied to recognize H2Sn in living tissues.
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