Journal
SCIENCE
Volume 363, Issue 6434, Pages 1447-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aav5297
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Funding
- New York Stem Cell Foundation
- NIMH [MH106475]
- NIDA [DA042012]
- Office of Naval Research [N000141812690]
- Simons Foundation [542987SPI]
- James S. McDonnell Foundation
- Stanford Interdisciplinary Graduate Fellowship
- U.S. Department of Defense (DOD) [N000141812690] Funding Source: U.S. Department of Defense (DOD)
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Ethologically relevant navigational strategies often incorporate remembered reward locations. Although neurons in the medial entorhinal cortex provide a maplike representation of the external spatial world, whether this map integrates information regarding learned reward locations remains unknown. We compared entorhinal coding in rats during a free-foraging task and a spatial memory task. Entorhinal spatial maps restructured to incorporate a learned reward location, which in turn improved positional decoding near this location. This finding indicates that different navigational strategies drive the emergence of discrete entorhinal maps of space and points to a role for entorhinal codes in a diverse range of navigational behaviors.
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