Journal
SCIENCE
Volume 363, Issue 6432, Pages 1191-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau6173
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Funding
- Milton Fund of Harvard University
- Searle Scholars Program
- Smith Family Foundation
- National Science Foundation [1652104]
- Helen Hay Whitney Foundation
- Human Frontier Science Program
- NIH [1R01HD080708-01, 5T32LM012417-03]
- Biomedical Big Training Program at UC Berkeley
- Marthella Foskett Brown Chair in Biological Sciences
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1652104] Funding Source: National Science Foundation
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Whole-body regeneration is accompanied by complex transcriptomic changes, yet the chromatin regulatory landscapes that mediate this dynamic response remain unexplored. To decipher the regulatory logic that orchestrates regeneration, we sequenced the genome of the acoel worm Hofstenia miamia, a highly regenerative member of the sister lineage of other bilaterians. Epigenomic profiling revealed thousands of regeneration-responsive chromatin regions and identified dynamically bound transcription factor motifs, with the early growth response (EGR) binding site as the most variably accessible during Hofstenia regeneration. Combining egr inhibition with chromatin profiling suggests that Egr functions as a pioneer factor to directly regulate early wound-induced genes. The genetic connections inferred by this approach allowed the construction of a gene regulatory network for whole-body regeneration, enabling genomics-based comparisons of regeneration across species.
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