Journal
REVIEWS IN THE NEUROSCIENCES
Volume 30, Issue 6, Pages 573-580Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/revneuro-2018-0084
Keywords
aging; Alzheimer's disease; brain; Hutchinson-Gilford progeria syndrome; stem cells
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Funding
- Russian Science Foundation [14-24-00107, 16-15-10108]
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Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism. In this work, we examine the distinctive features of brain aging and neurogenesis during normal aging, pathological aging (Alzheimer's disease), and accelerated aging (Hutchinson-Gilford progeria syndrome and Werner syndrome).
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