Journal
RESPIRATORY MEDICINE
Volume 148, Issue -, Pages 1-5Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2019.01.009
Keywords
Bronchiectasis; Vitamin D; Biomarker; Exacerbation; Severity
Ask authors/readers for more resources
Background: Bronchiectasis is a complex respiratory disease characterised by permanent dilatation of bronchi. Vitamin D plays a role in infective disease by modulating the inflammation. Patients affected by bronchiectasis are frequently Vitamin D deficient and it correlates with lung function decline. We want to understand if there is a correlation between Vitamin D and clinical and radiological severity of bronchiectasis. Methods: We included 57 patients (17 males/40 female with mean age 60 +/- 12 years) between October 2017 and March 2018. We excluded patients with cystic fibrosis, traction bronchiectasis and reporting Vitamin D supplementation. Bronchiectasis severity index (BSI) and Bhalla score were calculated, blood inflammatory markers and Vit. D were measured and lung function tests were performed. Results: Vitamin D is deficient in 64% of patients, sufficient in 36% and normal in 7%. Mean BSI is 7.5 +/- 5 and mean Bhalla score is 16 +/- 4. Vitamin D levels correlate with Bhalla score (R-2 = 0.68, p < 0.001) and BSI (R-2 = 0.58, p < 0.0001). The correlation appears to be stronger than other markers of inflammation such as ESR and CRP [R-2 = 0.33, p = 0.001 and R-2 = 0.39, p = 0.001 respectively]. Conclusions: We consider Vitamin D as a good predictor of clinical and radiological severity of bronchiectasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available