Journal
REGENERATIVE MEDICINE
Volume 14, Issue 3, Pages 213-230Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2018-0161
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Funding
- Magellan Stem Cells and Melbourne Stem Cell Centre
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Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods: 30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 x 10(6) ADMSCs) or two injections (100 x 10(6) ADMSCs at baseline and 6 months). The third group served as control and continued conservative management. Results: No serious adverse events were observed. Both treatment groups receiving ADMSCs showed clinically significant pain and functional improvement at completion of follow-up at 12 months. Radiological analysis using the Magnetic Resonance Imaging Osteoarthritis Knee Score indicated modification of disease progression. Conclusion: Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression.
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