Journal
REGENERATIVE MEDICINE
Volume 14, Issue 3, Pages 199-211Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2018-0063
Keywords
allograft; bone; intravenous injection; multipotent stromal cells; stromal cell-derived factor 1
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Funding
- Maryland Stem Cell Research Fund
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Aim: This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs). Materials & methods: After chemotactic and releasing assessments, stromal cell-derived factor 1 and platelet-derived growth factor BB in copolymers were coated on the bone allograft (Allo(S-P)). Allograft coated with copolymers alone (Allo), as controls, or Allo(S-P) was implanted into the femur of athymic mice, which received intravenous injections of human MSCs or saline at weeks 1, 2 and 3. Results: At week 8, the total callus volume (both cartilaginous and bony callus) around the allograft was the largest in the Allo(S-P) + MSC group (p < 0.05). Conclusion: Coating bone allograft with stromal cell-derived factor 1 and platelet-derived growth factor BB and intravenous injections of MSCs improved allograft incorporation.
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