Journal
PROTEIN AND PEPTIDE LETTERS
Volume 26, Issue 8, Pages 564-578Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406415666190222141905
Keywords
Antimicrobial peptides; bioactivity; molecular mechanisms; therapeutic potential; anticancer activity; antibacterial
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Funding
- National Natural Sciences Foundation of China [31470810]
- Science & Technology Depailment of Sichuan Province [2017JY0232]
- Health & Family Planning Commission of Sichuan Province [17ZD045]
- Chengdu Science and Technology Program [2017-GH02-00062-HZ]
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Antimicrobial Peptides (AMPs) are short amphipathic biological molecules generally with less than 100 amino acids. AMPs not only present high bioactivities against bacteria, fungi or protists-induced infections, but also play important roles in anticancer activity, immune response and inflammation regulation. AMPs are classified as ribosomally synthesized, non-ribosomally synthesized and post-translationally modified, non-ribosomally synthesized ones and several synthetic or semisynthetic peptides according to their synthesis with or without the involvement of ribosomes. The molecular characterization and hioactivity action mechanisms arc summarized for several ribosomally synthesized AMI's and main non-ribosomally synthesized members (cyclopeptides, lipopeptides, glycopeptides, lipoglycopeptides). We also analyze challenges and new strategies to overcome drug resistance and application limitations for AMP discovery. In conclusion, the growing novel small molecular AMPs have huge therapeutic potentials of antibacterial, antiviral, anticancer and immunoregulatory bioactivities through new techniques-driven drug discovery strategy including bioinformatics prediction, de novo rational design and biosynthesis.
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