Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 15, Pages 7513-7522Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1819095116
Keywords
behaving monkeys; somatosensory thalamocortical circuit; tactile detection task; simultaneous single-unit recordings; directed information-theoretic measure
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Funding
- Direccion General de Asuntos del Personal Academico de la Universidad Nacional Autonoma de Mexico [PAPIIT-IN202716, PAPIIT-IN210819]
- Consejo Nacional de Ciencia y Tecnologia [240892]
- Spanish Research Project [Agencia Estatal de Investigacion/Fondo Europeo de Desarrollo Regional (AEI/FEDER), European Union] [PSI2016-75688-P]
- European Union's Horizon 2020 Research and Innovation Programme [720270, 785907]
- Catalan Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) Programme 2017 Suport als Grups de Recerca (SGR) [1545]
- Pew Latin American Fellowship
- Charles H. Revson Biomedical Science Fellowship
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The direction of functional information flow in the sensory thalamocortical circuit may play a role in stimulus perception, but, surprisingly, this process is poorly understood. We addressed this problem by evaluating a directional information measure between simultaneously recorded neurons from somatosensory thalamus (ventral posterolateral nucleus, VPL) and somatosensory cortex (S1) sharing the same cutaneous receptive field while monkeys judged the presence or absence of a tactile stimulus. During stimulus presence, feed-forward information (VPL -> S1) increased as a function of the stimulus ampli- tude, while pure feed-back information (S1 -> VPL) was unaffected. In parallel, zero-lag interaction emerged with increasing stimulus amplitude, reflecting externally driven thalamocortical synchronization during stimulus processing. Furthermore, VPL -> S1 information decreased during error trials. Also, VPL -> S1 and zero-lag interaction decreased when monkeys were not required to report the stimulus presence. These findings provide evidence that both the direction of information flow and the instant synchronization in the sensory thalamocortical circuit play a role in stimulus perception.
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