Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 11, Pages 4940-4945Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1809105116
Keywords
sORF; peptide; respiration; mitochondria; lipid metabolism
Categories
Funding
- Boehringer Ingelheim Fond
- Skolkovo Institute of Science and Technology
- Russian Foundation for Basic Research (RFBR) [17-04-01904, 18-29-07005]
- Russian Science Foundation (RSF) [17-75-30027]
- Moscow State University Scientific School
- Russian Ministry of Science Grant [14.W03.31.0012]
- President's Scholarship [SP-4132.2018.4]
- RSF [17-15-01175]
- RFBR [18-54-74003]
- Russian Science Foundation [17-15-01175, 17-75-30027] Funding Source: Russian Science Foundation
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Genes coding for small peptides have been frequently misannotated as long noncoding RNA (lncRNA) genes. Here we have demonstrated that one such transcript is translated into a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this manuscript was under review. The Mtln peptide could be detected in mitochondria of mouse cell lines and tissues. In line with its mitochondrial localization, lack of the Mtln decreases the activity of mitochondrial respiratory chain complex I. Unlike the integral components and assembly factors of NADH: ubiquinone oxidoreductase, Mtln does not alter its enzymatic activity directly. Interaction of Mtln with NADH-dependent cytochrome b5 reductase stimulates complex I functioning most likely by providing a favorable lipid composition of the membrane. Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as lncRNAs, for the control of vitally important cellular processes.
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