Journal
ANALYTICAL SCIENCES
Volume 32, Issue 11, Pages 1189-1194Publisher
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.32.1189
Keywords
Cell motility; mechanobiology; nanomechanical sensors; cantilever-type sensors; membrane-type surface stress sensors (MSS); finite element analysis (FEA)
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Funding
- Ministry of Education, Culture, Sports, Science and Technolgy (MEXT), Japan [16K21602]
- MEXT, Japan [15H03588]
- World Premier International Research Center Initiative (WPI) on Materials Nanoarchitectonics (MANA)
- Grants-in-Aid for Scientific Research [15H03588, 16K21602] Funding Source: KAKEN
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Detection of cellular forces plays an important role in investigating the mechanical basis of cells. As nanomechanical sensors can directly detect surface stress, they can be utilized to detect cellular forces. In the present study, we perform quantitative simulations of nanomechanical sensors for the detection of cellular forces using finite element analyses (FEA). We focus on two types of nanomechanical sensors: a cantilever-type sensor and a membrane-type surface stress sensor (MSS). It is found that sensing signals can be obtained when cells on the nanomechanical sensors synchronize their motions. To effectively detect cellular forces on the nanomechanical sensors, we discuss the optimization scheme for a coating layer on the surface of the sensors.
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