Journal
ANALYTICAL METHODS
Volume 8, Issue 37, Pages 6682-6686Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ay01963c
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Funding
- CNPq [448089/2014-9, 444514/2014-7, 311744/2013-3]
- CAPES [3363/2014, 802-14]
- FAPEG
- FAPESP [2013/22127]
- INCTBio
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We describe for the first time the fabrication of a paper-based microchip electrophoresis (pME) device with integrated hand-drawn pencil electrodes to perform capacitively coupled contactless conductivity detection (C4D). This low-cost device (less than $0.10) revealed great capability to dissipate heat, good injection-to-injection repeatability, and ease of attaching pencil-drawn electrodes on the separation channel. The feasibility of the proposed pME-C4D device was successfully demonstrated with the separation of bovine serum albumin and creatinine within 150 s with baseline resolution. The limits of detection values for albumin and creatinine were 20 and 35 mu mol L-1, respectively. These biomolecules present clinical relevance as evidence of kidney failure. The proposed pME-C4D offers great potential to be explored in the diagnosis of diabetesmellitus and heart disease.
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