Journal
PHYTOCHEMISTRY
Volume 158, Issue -, Pages 46-55Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.11.003
Keywords
Aquilaria sinensis (Lour.) Spreng; Chinese agarwood; 2-(2-Phenylethyl)chromone dimer; Aquisinenone; Anti-inflammatory activity
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Funding
- National Natural Science Foundation of China [81503227, 81573572, 81530097]
- Project for Standardization of Chinese Materia Medica [ZYBZH-Y-GD-13-ZYY-2017-076]
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Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values in the range 0.6-37.1 mu M.
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