Journal
PEDIATRICS AND NEONATOLOGY
Volume 60, Issue 5, Pages 564-569Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.pedneo.2019.02.005
Keywords
birth weight; preterm newborns; probiotics
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Funding
- Instituto Mexicano del Seguro Social [FIS/IMSS/PROT/PRIO/12/019]
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Background: According to the literature, probiotics are an attractive alternative to prevent necrotizing enterocolitis (NEC). However, due to differences in probiotic composition, randomized controlled trials are necessary to compare different probiotic mixtures. The objective of this study was to compare single strain (Lactobacillus acidophilus boucardii) versus multispecies probiotics on NEC incidence and faecal secretory Immunoglobulin A (sIgA) levels in very low preterm newborns. Methods: We performed a double-blind randomized trial in 90 newborns. L. acidophilus boucardii strain or multispecies probiotics were randomly assigned to preterm newborns. As the primary outcome, we evaluated NEC incidence on the total length of neonatal intensive care unit (NICU) stay. As the secondary outcome, we measured the change in faecal sIgA levels from baseline to 3 weeks following the use of probiotics. Results: NEC incidence was similar between groups (0% vs. 2.2% for the single strain and multispecies probiotic, respectively). Faecal sIgA levels increased significantly (p < 0.001) within groups (31% for single strain and 47% for multispecies probiotic), but this increase was not different between groups. Neonates with a faecal sIgA level increment >0.45 mg/dl showed higher gestational age, birth weight, and weight at the second and third weeks of follow up than neonates with a faecal sIgA level increment <= 0.45 mg/dl. No adverse effects were found after probiotics use. Conclusions: No difference between strains of probiotics used was found on NEC incidence or in the increase of faecal sIgA levels. Faecal sIgA levels were positively related to gestational age and body weight in very low preterm infants. Copyright (C) 2019, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.
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