Journal
PEDIATRIC NEPHROLOGY
Volume 35, Issue 5, Pages 725-731Publisher
SPRINGER
DOI: 10.1007/s00467-019-04240-8
Keywords
Hedgehog; GLI; Stroma; Nephron; Ureteric; Pallister-Hall syndrome
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Aberrant hedgehog (Hh) signaling during embryogenesis results in various severe congenital abnormalities, including renal malformations. The molecular mechanisms that underlie congenital renal malformations remain poorly understood. Here, we review the current understanding of the lineage-specific roles of Hh signaling during renal morphogenesis and how aberrant Hh signaling during embryonic kidney development contributes to renal malformation.
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