Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 215, Issue 6, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2019.03.020
Keywords
Endometrial carcinoma; IL-6; Stat3; Invasion; Migration
Categories
Funding
- National Natural Science Foundation of China [81871183, 81701435, 81701470]
- Shanghai Committee of Science and Technology [18411963400]
- Youth Fund of Zhongshan Hospital, Fudan University [2017ZSQN33]
Ask authors/readers for more resources
Interleukin (IL)-6 is the most well-known traditional activator of activating signal transducers and activators of transcription 3 (Stat3). They have been proved to promote cancer progression in several human cancers. However, their exact roles in endometrial cancer have not been elucidated clearly. In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-induced MMP2 upregulation. Taken together, our findings indicate that targeting IL-6/Stat3 pathway might be a potentially effective therapeutic strategy for treating endometrial cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available