Journal
ANALYTICAL LETTERS
Volume 49, Issue 12, Pages 1847-1861Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2015.1128946
Keywords
Dopamine; functionalized graphene oxide; hydroxyethyl methacrylate; mass spectrometry; matrix-assisted laser desorption/ionization
Categories
Funding
- National Natural Science Foundation of China [81173025, 21445007]
- Fundamental Research Funds for the Central Universities [201402049]
Ask authors/readers for more resources
Dopamine is a neurotransmitter, whose concentration change causes various nervous system disorders such as Parkinson's disease. In this study, hydroxyethyl methacrylate-functionalized graphene oxide was prepared and used as the substrate for matrix-assisted laser desorption/ionization (MALDI) for the mass spectrometric determination of dopamine. The results show that hydroxyethyl methacrylate-functionalized graphene oxide materials may be used as a matrix for MALDI. This approach combines enrichment and detection in a single step. The new method greatly shortens the analysis time and significantly reduces the amount of sample required for the analysis. The detection limit of the method was 20 ng/mL. These features not only ensure that the method is suitable for trace analysis, but also extend the range of application of MALDI analysis to biochemical science.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available