Journal
ORGANIC LETTERS
Volume 21, Issue 8, Pages 2947-2951Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01016
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Funding
- ICIQ
- MINECO [CTQ2015-65496-R]
- La Caixa
- COFUND
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A Ni-catalyzed reductive deaminative arylation at unactivated sp(3) carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp(3) C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.
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