Journal
ORGANIC LETTERS
Volume 21, Issue 3, Pages 762-766Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b04010
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Funding
- Natural Science Foundation of China [21772003]
- 1000-Youth Talents Plan
- Peking University
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A general electrohemical strategy for the combined trifluoromethylation/C(sp(2))-H functionalization using Langlois' reagent as the CF3 source under oxidant-free conditions was developed. Using Mn salts as the redox mediator, this method provides an efficient and sustainable I means to access a variety of functionalized heterocycles bearing a CF3 moiety. Detailed mechanistic studies are consistent with the formation of CF3-bound high oxidation state Mn species, suggesting a transition-metal-mediated CF3 transfer mechanism for this trifluoromethylation/C(sp(2))-H functionalization process.
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