4.8 Article

Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups

Journal

ORGANIC LETTERS
Volume 21, Issue 8, Pages 2731-2735

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00695

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Funding

  1. National Natural Science Foundation of China [NSFC-21572178, NSFC-21702162]
  2. Natural Science Basic Research Plan in Shaanxi Province of China [2017JM2006]
  3. Key Science and Technology Innovation Team of Shaanxi Province [2017KCT-37]

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An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde beta-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C = C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.

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