Journal
ORGANIC LETTERS
Volume 21, Issue 9, Pages 3043-3047Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00572
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Funding
- National Natural Science Foundation of China [21602089]
- Natural Science Foundation of Jiangxi Province [20181BAB203004]
- Jiangxi Educational Committee [GJJ150321]
- Open Project Program of Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University [KLFS-KF-201622]
- Startup Foundation for Doctors of Jiangxi Normal University [5464]
- Foundation for Young People of Jiangxi Normal University
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An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scope, good regioselectivity, high efficiency, and easy operation.
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