4.8 Article

Copper-Catalyzed Intermolecular Carboamination of Alkenes Induced by Visible Light

Journal

ORGANIC LETTERS
Volume 21, Issue 6, Pages 1699-1703

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00252

Keywords

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Funding

  1. NSFC [21772218, 21821002, XDB20000000]
  2. Thousand Plan Youth program, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry
  3. Chinese Academy of Sciences

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A photoinduced copper-catalyzed three-component reaction involving carbohalide, alkene and amine has been developed, leading to valuable fluoroalkyl-containing amines. A sole inexpensive CuCl is used as the photo- and coupling catalyst. A broad array of substrates are capable coupling partners. The diverse method is compatible with a broad range of functional groups and can be further applied to the late-stage functionalization of bioactive pharmaceuticals.

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