Journal
ORGANIC LETTERS
Volume 21, Issue 5, Pages 1426-1429Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00165
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Funding
- Thousand Youth Talents Plan, Shanghai Institute of Organic Chemistry, State Key Laboratory of Organometallic Chemistry
- Scripps Research Institute
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A rapid synthesis of beta-arylethenesulfonyl fluorides is realized using ligand-accelerated Pd(II)-catalyzed nondirected C-H alkenylation of simple arenes. The newly developed electron-deficient 2-pyridone ligand is crucial for this transformation with arenes as limiting reagent. This protocol features a broad substrate scope and good functional group tolerance. Late-stage functionalization of various pharmaceuticals and their further click manipulations demonstrate this procedure to be highly valuable.
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