Journal
ORGANIC LETTERS
Volume 21, Issue 4, Pages 913-916Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03840
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21672098, 21732003]
- National Key Research and Development Program of China [2018YFC0310900]
Ask authors/readers for more resources
A photoredox/amine-cocatalyzed enantioselective radical hydroacylation of enals with alpha-ketoacids is described. Acyl radicals generated from alpha-ketoacids act as the acylation reagent with the iminium ions. This strategy provides an efficient way to access synthetically challenging 1,4-dicarbonyl compounds in an enantioselective manner. The reactions of various enals with alpha-ketoacids show the generality and limitations of this method.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available