Journal
ORGANIC LETTERS
Volume 21, Issue 4, Pages 862-866Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03501
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Funding
- JSPS KAKENHI [17K01966]
- Grants-in-Aid for Scientific Research [17K01966] Funding Source: KAKEN
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Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of intracellular fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups.
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