Journal
ORAL DISEASES
Volume 25, Issue 4, Pages 1057-1066Publisher
WILEY
DOI: 10.1111/odi.13049
Keywords
lymphocyte; neutrophil; oral squamous cell carcinoma; platelet; PNL score; prognosis
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Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions [2014-37]
- Natural Scientific Foundation of the Jiangsu Higher Education Institutions of China [16KJB320002]
- Natural Science Foundation of Jiangsu Province [BK20151561, BK20161564, BK20161024]
- National Natural Science Foundation of China [81572669, 81602386, 81602378]
- Nanjing Municipal Committee of Science and Technology [201803044]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_1510]
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Objective Circulating immune-inflammatory cells have been increasingly recognized as robust prognostic biomarkers in cancer. Here, we sought to evaluate the prognostic values of preoperative peripheral platelet, neutrophil, lymphocyte quantitation in patients with primary oral squamous cell carcinoma (OSCC). Materials and methods A total number of 309 patients with primary OSCC surgically treated at our institutions were retrospectively included. Detailed demographic, clinicopathological, laboratory, and follow-up data were collected. The Kaplan-Meier analysis and Cox regression assay were performed to assess the prognostic values. A new prognostic risk score was developed and designed as PNL (platelet-neutrophil-lymphocyte) score based on combined preoperative platelets, neutrophils, and lymphocytes via calculating the regression coefficients of each type of cell by Cox regression analysis. Results High platelet counts (>= 266 x 10(9)/L), neutrophil counts (>= 2.8 x 10(9)/L), PNL scores, and low lymphocyte counts (<1.4 x 10(9)/L) significantly associated with reduced overall and disease-free survival (Kaplan-Meier, p < 0.05, Log-rank test). Univariate and multivariate regression analyses revealed that individual platelet, neutrophil, lymphocyte quantitation, and PNL score were independent prognostic predictors for patient survival. Moreover, receiver operating characteristics curve revealed superior prognostic utility of PNL score for OSCC. Conclusions Our findings indicate that preoperative circulating platelets, neutrophils, lymphocytes, and PNL score serve as noninvasive, low-cost, and powerful prognostic predictors for patients with OSCC.
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